What are orofacial clefts (OFCs)? Orofacial clefts (OFCs) are a group of birth anomalies which occur during fetal development, and refer to cleft lips, palates (the roof of the mouth), or a combination of both. When in the womb, the lip and mouth both form during the first trimester (CDC). Depending on the individual, both types of OFCs can range...